About us

Groups at the CRG's Bioinformatics and Genomics program perform research in Biology using computation. Focus is on Genomics and Evolution.

We use computation as a means both to interrogate and to model biological phenomena. We use existing tools, but we also design and implement novel computational tools and databases, and we are also interested in basic research in algorithms.

The Groups at CRG's Bioinformatics and Genomics Program have strong collaborations with the CRG's Bioinformatics core and with other experimental groups at the CRG. We believe that it is at the intersection between Experimentation and Computation that the Biology of the XXIst century will be edificated, and at the program we have our own experimental laboratory.  

We have also strong collaborations with the Research Group of Biomedical Informatics (GRIB, from the UPF-IMIM, http://grib.imim.es), and with the computatational genomics groups at the GRIB, we form the computational genomics cluster at the PRBB (http://genome.prbb.cat).


Development of algorithms and software for the comparison of biological recordings such as sequences, genomes, phenotypes and structures

Using comparative genomics and evolutionary analyses to understand complex biological systems

Investigation of sequence patterns in the genome responsible for functionality

Computational and Theoretical investigation of the evolution of genes and genomes

Predictions of Interactomes and Evolution of Proteomes

Evaluation of how different types of genetic variants, epigenetic modifications and non-coding RNA pathways contribute to human disorders.


Research on bioinformatics and computational genomics

PhylomeDB V4 released

The new version of PhylomeDB has been released. Version 4  

X CRG Annual Symposium "Computational Biology of Molecular Sequences" (10-11 November 2011)

On the 10-11 of November 2011 our group headed by Roderic Guigo will be organizing a two-day CRG symposium on “Computational Biology of Molecular Sequences” which will bring together renowned Computational Biologists from around the world, including both pioneers in the field, as well as promising young scientists. Presentations, discussions and dialogue during the Symposium will contribute to survey the status of a discipline that, at the intersection of Biology and Computation, will have an enormous impact on the world of the XXIst century.

You may obtain more information on the objectives of the symposium, the current list of confirmed speakers and instructions on how to register by clicking here. The poster of the symposium can be downloaded by clicking here.

MetaPhOrs: orthologs and paralogs accross 829 genomes, based on multiple phylogenetic evidence

We have launched MetaPhOrs, a meta-method to predict orthology and paralogy from multiple phylogenetic evidence. To maximize reliability and coverage, we retrieved gene trees from PhylomeDB, Ensembl, TreeFam and Orthogroups. In addition we built maximum likelihood trees for orthologous gene families in OrthoMCL, COG, and EggNOG.


PhylomeDB v3.0 released

A new version of PhylomeDB has been released. With over 400.000 phylogenetic trees, PhylomeDB is currently the major public phylogenetic repository. It contains phylomes from model (Human, Yeast, Drosophila, Arabidopsis), but also alternative models such as the fungal pathogen Candida albicans, or the insects T. castaneum, N. vitripenis  and A. pisum.  New features have been added to the user's front end, including fully interactive tree images and link outs to external information.


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Gene Function and Evolution

Group leader:  Gian Gaetano Tartaglia
Predictions of Interactomes and Evolution of Proteomes


IX CRG Annual Symposium (Medical Genome Sequencing: Understanding the genomes of disease)

This symposium was organized by Roderic Guigo and Xavier Estivill and held on the 28-29 Oct 2010. It aimed at establishing a forum for capturing the latest advances in genomic sequencing technologies and its various medical applications. The two-day meeting featured talks by international keynote speakers outlining the current status of medical sequencing, and putting forth the technological challenges ahead. More information on this past event can be obtained by clicking here.

Long Noncoding RNAs with Enhancer-like Function in Human Cells

Roderic Guigo and former post-Doc Thomas Derrien were involved in a study recently published in the journal Cell that looked into the function of the long noncoding RNAs (ncRNAs). This type of RNA molecule constitutes a large portion of the mammalian transcriptome even though their biological functions remained unclear. This study helped shed light on the role of long ncRNAs. For example it was shown 1) that long ncRNAs activate neighboring protein-coding genes, 2) activating long ncRNAs have a similar behavior to that of enhancer elements and 3) more specifically, the depletion of both genes directly involved in hematopoiesis or its adjacent ncRNA both show similar cellular migration defects.


Sequence Mapping and Assembly Assessment Project (SMAAP): RGASP3/dnGASP

SMAAP (RGASP3/dnGASP) is a collaborative effort among researchers to compare and evaluate methods and strategies for de novo genome assembly and RNASeq read alignment using data from 2nd generation sequencing platforms.

Roderic Guigo of the CRG and Ivo Gut of the CNAG will be coordinating the upcoming RGASP3 project.

The rules and all current information concerning RGASP3 and dnGASP can be found on this page.

This project is a collaboration between the CRG, CNAG (Barcelona) and the Sanger Centre (Hixton, UK).



The Institute:

The Centre for Genomic Regulation (CRG) is an innovative centre created in December 2000 and located in the Barcelona Biomedical Research Park (PRBB). The mission of the CRG is to promote excellent basic research in biomedicine, cutting-edge technology development and high quality training of the next generation of scientists.

CRG has a highly international culture and the working language is English.

For more information visit our website http://www.crg.es

Post Description:

"Symposium: The ENCODE project ten years after the human genome sequence"

More than two years into the scaling phase of the ENCODE project, and as one of the active ENCODE research units our group hosted the ENCODE Analysis Working group which met in Barcelona to discuss the challenges of analyzing the great amount of data being produced by the project.

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