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Misidentification of genome assemblies in public databases: the case of Naumovozyma dairenensis and proposal of a protocol to correct misidentifications

12 Jan 2018
ABSTRACT: Online sequence databases such as NCBI GenBank serve as a tremendously useful platform for researchers to share and reuse published data. However, submission systems lack control for errors such as organism misidentification, which once entered in the database can be propagated and mislead downstream analyses. Here we present an illustrating case of misidentification of Candida albicans ...
Publications
Boekhout Lab
Gabaldón Lab

Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin

7 Nov 2017
ABSTRACT: Candida albicans is a dimorphic commensal fungus that causes severe oral infections in immunodeficient patients. Invasion of C. albicans hyphae into oral epithelium is an essential virulence trait. Interleukin-17 (IL-17) signaling is required for both innate and adaptive immunity to C. albicans . During the innate response, IL-17 is produced by γδ T cells and a poorly understood ...
Publications
Hube Lab

Hybridization and emergence of virulence in opportunistic human yeast pathogens

6 Jul 2017
ABSTRACT: Hybridization between different species can result in the emergence of new lineages and adaptive phenotypes. Occasionally, hybridization in fungal organisms can drive the appearance of opportunistic lifestyles or shifts to new hosts, resulting in the emergence of novel pathogens. In recent years, an increasing number of studies have documented the existence of hybrids in diverse yeast ...
Publications
Gabaldón Lab

Widespread Inter- and Intra-Domain Horizontal Gene Transfer of D-Amino Acid Metabolism Enzymes in Eukaryotes

17 Jan 2017
ABSTRACT: Analysis of the growing number of available fully-sequenced genomes has shown that Horizontal Gene Transfer (HGT) in eukaryotes is more common than previously thought. It has been proposed that genes with certain functions may be more prone to HGT than others, but we still have a very poor understanding of the selective forces driving eukaryotic HGT. Recent work uncovered that D-amino ...
Publications
Gabaldón Lab
Hube Lab

Effects of the glucocorticoid betamethasone on the interaction of Candida albicans with human epithelial cells

7 Dec 2016
ABSTRACT: The glucocorticoid betamethasone (BM) is frequently employed in the clinical practice because of its anti-inflammatory and immunosuppressive properties. In this study, we investigated the effect of BM (1 and 2 mM) on the ability of Candida albicans to adhere to, invade and damage oral, intestinal or vaginal epithelial cells, as well as to elicit cytokine and chemokine release. BM at 2 ...
Publications
Hube Lab

Evolutionary genomics of yeast pathogens in the Saccharomycotina

3 Aug 2016
ABSTRACT: Saccharomycotina comprises a diverse group of yeasts that includes numerous species of industrial or clinical relevance. Opportunistic pathogens within this clade are often assigned to the genus Candida but belong to phylogenetically distant lineages which also comprise non-pathogenic species. This indicates that the ability to infect humans has evolved independently several times among ...
Publications
Gabaldón Lab

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