This ESR's goal will be to establish an integrated diagnostic system for early and robust diagnosis, including detection and identification of resistant Candida pathogens.
To validate in the clinic the innovative detection tools developed in WPs 2-5.
Validation will be done on prospective clinical studies, the patient sample library (Biobank, P8) and by application of animal infection models. Clinical validation will include comparison with currently used methods, and a blind test set of yeast isolates (by P2) and previously diagnosed material from the Biobank of P8. P9 will contribute by evaluating the P8 approved and final set of OPATHY diagnostics. ESR11 will also participate in coupling antibodies from WP3 with ELISA-based formats or lateral flow devices.
An overview of the project can be downloaded here: