This ESR's goal will be to identify a set of resistance markers for azole and echinocandin resistant yeasts to be developed in to diagnostic markers.
Objectives:
To investigate polymorphisms in genes involved in resistance and the design of probes to detect them.
Methodology:
In collaboration with ESR13 (P7) we will explore the expression of specific proteins of resistant and susceptible isolates under conditions of antifungal drugs stress. Bioinformatics analysis will identify biomolecules that correlate with the resistance, and these will be characterized. Comparative genomics, transcriptomics and proteomics (MALDI-TOF MS) will identify markers that are related to the resistance [or the susceptibility]. These will be subsequently explored for the development of diagnostic probes that will be clinically tested by P8 (IMU).
An overview of the project can be downloaded here:
Project supervisors
Host Institute
