ABSTRACT: Online sequence databases such as NCBI GenBank serve as a tremendously useful platform for researchers to share and reuse published data. However, submission systems lack control for errors such as organism misidentification, which once entered in the database can be propagated and mislead downstream analyses. Here we present an illustrating case of misidentification of Candida albicans ...
ABSTRACT: Candida albicans is a dimorphic commensal fungus that causes severe oral infections in immunodeficient patients. Invasion of C. albicans hyphae into oral epithelium is an essential virulence trait. Interleukin-17 (IL-17) signaling is required for both innate and adaptive immunity to C. albicans . During the innate response, IL-17 is produced by γδ T cells and a poorly understood ...
Vaezi, A., Fakhim, H., Arastehfar, A., Shokohi, T., Hedayati, M. T., Khodavaisy, S., ... & Dannaoui, E. (2018). In vitro antifungal activity of amphotericin B and 11 comparators against Aspergillus terreus species complex. Mycoses, 61(2), 134-142.
Aspergillus terreus infections are difficult to treat because of the intrinsic resistance to amphotericin B, and higher mortality compared to infections caused by other Aspergillus species. The aim of the present study was to determine the in vitro antifungal activity of amphotericin B and 11 comparators against clinical (n = 36) and environmental (n = 45) A. terreus isolates. In vitro antifungal susceptibility was performed using the CLSI M38‐A2 procedure. Amphotericin B exhibited the highest MICs (MIC range, 0.125‐4 μg/mL; MIC90, 2 μg/mL), followed by terbinafine (MIC range, 0.002‐1 μg/mL; MIC90, 1 μg/mL). Only one isolate (1/81) showed amphotericin B MIC above the epidemiologic cut‐off value (ECV; 4 μg/mL). None of the isolates had a MIC of ≥ ECV for voriconazole, itraconazole and posaconazole. The reasons for the difference in amphotericin B susceptibility patterns between studies remain unknown. The genetic and species diversity, clinical, environmental and ecological factors in Terrei section on various amphotericin B susceptibility profiles in different countries should be considered more as the main reasons associated with these differences.
During the HFP2017 conference in La-Colle-Sur-Loupe, France, OPATHY scientific advisory board member Judith Berman (Tel Aviv University) was interviewed by OPATHY ESR Elise Iracane (University College Dublin).
ABSTRACT: Hybridization between different species can result in the emergence of new lineages and adaptive phenotypes. Occasionally, hybridization in fungal organisms can drive the appearance of opportunistic lifestyles or shifts to new hosts, resulting in the emergence of novel pathogens. In recent years, an increasing number of studies have documented the existence of hybrids in diverse yeast ...
The 2017 MCAA Conference and General Assembly will be held on Friday 24th and Saturday 25th March 2017 in Salamanca, Spain. The host for this event is the University of Salamanca, in cooperation with the MCAA Spain/Portugal Chapter. The winner of the BCN Science Slam will present on a Science Slam which will take place on 24th of March as a side program of the MCAA general assembly meeting.
