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25 Jan 2018
ABSTRACT: Invasive candidiasis is among the most life-threatening infections in patients in intensive care units. Although Candida albicans is the leading cause of candidaemia, the incidence of Candida parapsilosis infections is also rising, particularly among the neonates. Due to differences in their biology, these species employ different antifungal resistance and virulence mechanisms and also ...
25 Jan 2018
ABSTRACT: RNA molecules play important roles in virtually every cellular process. These functions are often mediated through the adoption of specific structures that enable RNAs to interact with other molecules. Thus, determining the secondary structures of RNAs is central to understanding their function and evolution. In recent years several sequencing-based approaches have been developed that ...
15 Jan 2018
ABSTRACT: Candida spp. are leading causes of opportunistic mycoses, including life-threatening hospital-borne infections, and novel antifungals, preferably aiming targets that have not been used before, are constantly needed. Hydrazone- and guanidine-containing molecules have shown a wide range of biological activities, including recently described excellent antifungal properties. In this study, ...
12 Jan 2018
ABSTRACT: Online sequence databases such as NCBI GenBank serve as a tremendously useful platform for researchers to share and reuse published data. However, submission systems lack control for errors such as organism misidentification, which once entered in the database can be propagated and mislead downstream analyses. Here we present an illustrating case of misidentification of Candida albicans ...
7 Nov 2017
ABSTRACT: Candida albicans is a dimorphic commensal fungus that causes severe oral infections in immunodeficient patients. Invasion of C. albicans hyphae into oral epithelium is an essential virulence trait. Interleukin-17 (IL-17) signaling is required for both innate and adaptive immunity to C. albicans . During the innate response, IL-17 is produced by γδ T cells and a poorly understood ...
24 Oct 2017
Vaezi, A., Fakhim, H., Arastehfar, A., Shokohi, T., Hedayati, M. T., Khodavaisy, S., ... & Dannaoui, E. (2018). In vitro antifungal activity of amphotericin B and 11 comparators against Aspergillus terreus species complex. Mycoses, 61(2), 134-142.
24 Oct 2017
Aspergillus terreus infections are difficult to treat because of the intrinsic resistance to amphotericin B, and higher mortality compared to infections caused by other Aspergillus species. The aim of the present study was to determine the in vitro antifungal activity of amphotericin B and 11 comparators against clinical (n = 36) and environmental (n = 45) A. terreus isolates. In vitro antifungal susceptibility was performed using the CLSI M38‐A2 procedure. Amphotericin B exhibited the highest MICs (MIC range, 0.125‐4 μg/mL; MIC90, 2 μg/mL), followed by terbinafine (MIC range, 0.002‐1 μg/mL; MIC90, 1 μg/mL). Only one isolate (1/81) showed amphotericin B MIC above the epidemiologic cut‐off value (ECV; 4 μg/mL). None of the isolates had a MIC of ≥ ECV for voriconazole, itraconazole and posaconazole. The reasons for the difference in amphotericin B susceptibility patterns between studies remain unknown. The genetic and species diversity, clinical, environmental and ecological factors in Terrei section on various amphotericin B susceptibility profiles in different countries should be considered more as the main reasons associated with these differences.
6 Sep 2017
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4 Sep 2017
The second OPATHY Annual Meeting/ Summer School took place from 27th of August till 1st of September at Hans-Knoell-Institute in Jena, Germany.
4 Aug 2017
During the HFP2017 conference in La-Colle-Sur-Loupe, France, OPATHY scientific advisory board member Judith Berman (Tel Aviv University) was interviewed by OPATHY ESR Elise Iracane (University College Dublin).