This ESR's goal will be to identify markers and transcriptional profiles common to fungal infection, and specific to C. albicans and C. glabrata infection.
This ESR's goal will be to establish an integrated diagnostic system for early and robust diagnosis, including detection and identification of resistant Candida pathogens.
This ESR's goal will be to identify virulence factors up-regulated in C. albicans and the host, as compared to uninfected women with normal vaginal microflora. Candidate genes will be developed into prototype diagnostic tools.
This ESR's goal will be to increase the understanding of how host-pathogen interactions vary during infection and across Candida species by comparative genome approaches.
This ESR's goal will be to increase the understanding of how host-pathogen interactions vary during infection and across Candida species by comparative transcriptome approaches.
This ESR's goal will be to identify a set of candidate and validated nucleotide domains that are useful for the development of diagnostic probes/primers of pathogenic yeast species and groups thereof.
This ESR's goal will be to identify potential biomarkers from data-mining approaches and to build up a central OPATHY database and new computational analyses workflows.
This ESR's goal will be to identify antifungal resistance biomarkers in main pathogenic Candida species and the isolation and assessment of llama antibodies against selected candidate biomarkers.
This ESR's goal will be to establish a general protocol for enrichment of Candida yeast cells out of body fluids and subsequent MALDI-TOF analysis directly on clinical samples.
This ESR's goal will be to identify a panel of purification columns based on the selected llama antibodies that have proven functionality on beads to purify and diagnose Candida species from clinical samples.
